15.1 million euros have been awarded to 14 excellent projects under the call JTC 2022 on “Novel translational approaches to tackle the challenges of hard-to-treat cancers from early diagnosis to therapy”.
The awarded projects are listed below in alphabetical order according to their acronym.
Project Acronym | Project Title |
| ANGELA | Early detection of esophageal squamous cell carcinoma with the Cytosponge coupled with molecular biomarkers and machine learning |
| BileCanMet | Precision medicine in cholangiocarcinoma: accurate tools for early detection and identification of PRMT5 as a novel pharmacological target |
| CAR4PDAC | Hijacking stroma antigens for CAR-T cell immunotherapy of PDAC |
| iCC-Strat | Risk stratification and subtyping of intrahepatic cholangiocarcinoma for early detection of recurrence and response to immuno-therapy |
| IdeaTMEHCC | Identification of therapeutic targets using HCC DErived organoid Augmented with TME components. |
| MATTO-GBM | Multimodality Artificial intelligence open-source Tools for Radiation Treatment Optimization in patients with Glioblastoma |
| NK-4-GBM | Metabolically optimised NK cell therapies for Glioblastoma |
| PaCaNano | Development of a pancreatic cancer drug-nanocarrier system selectively targeting tumour cells and tumour stroma to overcome treatment failure |
| PANC-P53 | Innovative peptide- and RNA-based strategies to modulate p53 for pancreatic cancer therapy |
| PLASTIG | Tackling tumor heterogeneity and PLASTIcity as resistance mechanisms in Glioblastoma |
| PRECEDENCE | Genotype matched therapies in intrahepatic cholangiocarcinoma: a multi-pronged strategy for improving efficacy and combating resistance. |
| ReachGLIO | Reaching the heterogeneous vascular landscape of glioblastoma with multifunctional nanomedicines. |
| SIMMBAP | Systemic immunological determinants of tumor evolution and therapy response in BRCA-mutated pancreatic cancer |
| T-Plex EAC | T-Plex-Capture: Isolation of neoantigen-specific CD8+ T cell receptors for patient-specific immunotherapy in esophageal adenocarcinoma (EAC) |