Below is the list of selected projects under the co-funded call JTC 2021 on "Next generation cancer immunotherapy: targeting the tumour microenvironment" .
Proposals are presented in alphabetical order according to their acronym.
Acronym | Title |
ANEMONE | The ANswer within the microEnvironment: Malignant pleural mesothelioma resistance to Old and NEw drugs |
BIALYMP | Bispecific antibodies in Lymphoma: Microenvironmental profiling to predict treatment response and uncover immunogenic resistance mechanisms |
CHRYSALIS | Characterization of stromal and innate lymphoid cell populations involved in immunotherapy resistance in High-Grade Serous Ovarian |
IMMOSCAN | The role of IMMune OSteoclasts in CANcer – Implications for therapy |
ImmuMet | Invigorating immunity against brain metastases in lung and breast cancer patients |
iParaCyts | Understanding and therapeutically exploiting the immunosuppressive paracrine signalling in the tumour microenvironment of metastatic lesions |
LipidMac | Exploiting lipid-laden macrophages to overcome resistance to cancer immunotherapy |
MAGNOLIA | MAppinG adaptatioN Of tripLe negative breast cancer microenvironments to ImmunotherApy |
PERIMMUNE | Intraperitoneal Immune Modulation for Colorectal Peritoneal Metastases |
PIXEL | Profiling and functional analysis of the Immune environment of eXtramedullary leukemia rELapses |
PREDICO | Defining Predictive Immunedeterminants of response to neoadjuvant Chemoradiation in Oesophageal adenocarcinoma |
Pur-Ther | New immunotherapies targeting the key purinergic checkpoints in the tumor microenvironment |
RISEBrain | Reverting immune suppression to elicit brain metastasis control |
SmartCAR-T | SmartCAR-T - Reprogramming of the tumor microenvironment with modular engineered CAR-T cells to augment the efficacy of immunotherapy |
TALETE | TArgeting acute myeloid Leukemia immunosuppressive microEnvironment by combined IDO1 inhibiTion and PD-1 blockadE |
TANGERINE | Artificial-intelligence-based end-to-end prediction of cancer immunotherapy response |
TENACITY | TargEting the Nectin fAmily to boost Cancer ImmuniTY |
TRanSLIT | Targeting ROBOs and SLIT guidance cues in the immune-suppressive stromal context of pancreatic cancer (TRanSLIT) |
TumorOUT | Innovative mRNA vaccine against NSCLC: Designing a platform of targeted polymeric nanoparticles for efficient personalized therapy |
UCIPredict | Circulating tumour microenvironment components as Urothelial Cancer Immunotherapy Response Predictors |