Results of the co-funded call JTC 2021

20 consortia were selected for funding with a total amount of requested budget of €25.9 million.

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Below is the list of selected projects under the co-funded call JTC 2021 on "Next generation cancer immunotherapy: targeting the tumour microenvironment" .

Proposals are presented in alphabetical order according to their acronym.

Acronym

Title

ANEMONE

The ANswer within the microEnvironment: Malignant pleural mesothelioma resistance to Old and NEw drugs

BIALYMP

Bispecific antibodies in Lymphoma: Microenvironmental profiling to predict treatment response and uncover immunogenic resistance mechanisms

CHRYSALIS

Characterization of stromal and innate lymphoid cell populations involved in immunotherapy resistance in High-Grade Serous Ovarian

IMMOSCAN

The role of IMMune OSteoclasts in CANcer – Implications for therapy

ImmuMet

Invigorating immunity against brain metastases in lung and breast cancer patients

iParaCyts

Understanding and therapeutically exploiting the immunosuppressive paracrine signalling in the tumour microenvironment of metastatic lesions

LipidMac

Exploiting lipid-laden macrophages to overcome resistance to cancer immunotherapy

MAGNOLIA

MAppinG adaptatioN Of tripLe negative breast cancer microenvironments to ImmunotherApy

PERIMMUNE

Intraperitoneal Immune Modulation for Colorectal Peritoneal Metastases

PIXEL

Profiling and functional analysis of the Immune environment of eXtramedullary leukemia rELapses

PREDICO

Defining Predictive Immunedeterminants of response to neoadjuvant Chemoradiation in Oesophageal adenocarcinoma

Pur-Ther

New immunotherapies targeting the key purinergic checkpoints in the tumor microenvironment

RISEBrain

Reverting immune suppression to elicit brain metastasis control

SmartCAR-T

SmartCAR-T - Reprogramming of the tumor microenvironment with modular engineered CAR-T cells to augment the efficacy of immunotherapy

TALETE

TArgeting acute myeloid Leukemia immunosuppressive microEnvironment by combined IDO1 inhibiTion and PD-1 blockadE

TANGERINE

Artificial-intelligence-based end-to-end prediction of cancer immunotherapy response

TENACITY

TargEting the Nectin fAmily to boost Cancer ImmuniTY

TRanSLIT

Targeting ROBOs and SLIT guidance cues in the immune-suppressive stromal context of pancreatic cancer (TRanSLIT)

TumorOUT

Innovative mRNA vaccine against NSCLC: Designing a platform of targeted polymeric nanoparticles for efficient personalized therapy

UCIPredict

Circulating tumour microenvironment components as Urothelial Cancer Immunotherapy Response Predictors